diff --git a/src/test/system_tests.cpp b/src/test/system_tests.cpp
index 90fce9adf9..76a8f80ba1 100644
--- a/src/test/system_tests.cpp
+++ b/src/test/system_tests.cpp
@@ -29,12 +29,23 @@ BOOST_AUTO_TEST_CASE(dummy)
 
 BOOST_AUTO_TEST_CASE(run_command)
 {
+#ifdef WIN32
+    // https://www.winehq.org/pipermail/wine-devel/2008-September/069387.html
+    auto hntdll = GetModuleHandleA("ntdll.dll");
+    assert(hntdll);
+    const bool wine_runtime = GetProcAddress(hntdll, "wine_get_version");
+#endif
+
     {
         const UniValue result = RunCommandParseJSON("");
         BOOST_CHECK(result.isNull());
     }
     {
+#ifdef WIN32
+        const UniValue result = RunCommandParseJSON("cmd.exe /c echo {\"success\": true}");
+#else
         const UniValue result = RunCommandParseJSON("echo \"{\"success\": true}\"");
+#endif
         BOOST_CHECK(result.isObject());
         const UniValue& success = result.find_value("success");
         BOOST_CHECK(!success.isNull());
@@ -42,7 +53,11 @@ BOOST_AUTO_TEST_CASE(run_command)
     }
     {
         // An invalid command is handled by Boost
+#ifdef WIN32
+        const int expected_error{wine_runtime ? 6 : 2};
+#else
         const int expected_error{2};
+#endif
         BOOST_CHECK_EXCEPTION(RunCommandParseJSON("invalid_command"), boost::process::process_error, [&](const boost::process::process_error& e) {
             BOOST_CHECK(std::string(e.what()).find("RunCommandParseJSON error:") == std::string::npos);
             BOOST_CHECK_EQUAL(e.code().value(), expected_error);
@@ -51,7 +66,11 @@ BOOST_AUTO_TEST_CASE(run_command)
     }
     {
         // Return non-zero exit code, no output to stderr
+#ifdef WIN32
+        const std::string command{"cmd.exe /c exit 1"};
+#else
         const std::string command{"false"};
+#endif
         BOOST_CHECK_EXCEPTION(RunCommandParseJSON(command), std::runtime_error, [&](const std::runtime_error& e) {
             const std::string what{e.what()};
             BOOST_CHECK(what.find(strprintf("RunCommandParseJSON error: process(%s) returned 1: \n", command)) != std::string::npos);
@@ -60,8 +79,13 @@ BOOST_AUTO_TEST_CASE(run_command)
     }
     {
         // Return non-zero exit code, with error message for stderr
+#ifdef WIN32
+        const std::string command{"cmd.exe /c dir nosuchfile"};
+        const std::string expected{wine_runtime ? "File not found." : "File Not Found"};
+#else
         const std::string command{"ls nosuchfile"};
         const std::string expected{"No such file or directory"};
+#endif
         BOOST_CHECK_EXCEPTION(RunCommandParseJSON(command), std::runtime_error, [&](const std::runtime_error& e) {
             const std::string what(e.what());
             BOOST_CHECK(what.find(strprintf("RunCommandParseJSON error: process(%s) returned", command)) != std::string::npos);
@@ -71,10 +95,15 @@ BOOST_AUTO_TEST_CASE(run_command)
     }
     {
         // Unable to parse JSON
+#ifdef WIN32
+        const std::string command{"cmd.exe /c echo {"};
+#else
         const std::string command{"echo {"};
+#endif
         BOOST_CHECK_EXCEPTION(RunCommandParseJSON(command), std::runtime_error, HasReason("Unable to parse JSON: {"));
     }
-    // Test std::in
+    // Test std::in, except for Windows
+#ifndef WIN32
     {
         const UniValue result = RunCommandParseJSON("cat", "{\"success\": true}");
         BOOST_CHECK(result.isObject());
@@ -82,6 +111,7 @@ BOOST_AUTO_TEST_CASE(run_command)
         BOOST_CHECK(!success.isNull());
         BOOST_CHECK_EQUAL(success.get_bool(), true);
     }
+#endif
 }
 #endif // ENABLE_EXTERNAL_SIGNER