diff --git a/CMakeLists.txt b/CMakeLists.txt
index 3b033383d8..3d43079b33 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -30,6 +30,22 @@ set(CLIENT_VERSION_RC 0)
 set(CLIENT_VERSION_IS_RELEASE "false")
 set(COPYRIGHT_YEAR "2024")
 
+# During the enabling of the CXX and CXXOBJ languages, we modify
+# CMake's compiler/linker invocation strings by appending the content
+# of the user-defined `APPEND_*` variables, which allows overriding
+# any flag. We also ensure that the APPEND_* flags are considered
+# during CMake's tests, which use the `try_compile()` command.
+#
+# CMake's docs state that the `CMAKE_TRY_COMPILE_PLATFORM_VARIABLES`
+# variable "is meant to be set by CMake's platform information modules
+# for the current toolchain, or by a toolchain file." We do our best
+# to set it before the `project()` command.
+set(CMAKE_TRY_COMPILE_PLATFORM_VARIABLES
+  CMAKE_CXX_COMPILE_OBJECT
+  CMAKE_OBJCXX_COMPILE_OBJECT
+  CMAKE_CXX_LINK_EXECUTABLE
+)
+
 project(BitcoinCore
   VERSION ${CLIENT_VERSION_MAJOR}.${CLIENT_VERSION_MINOR}.${CLIENT_VERSION_BUILD}
   DESCRIPTION "Bitcoin client software"
@@ -189,6 +205,16 @@ cmake_dependent_option(BUILD_FOR_FUZZING "Build for fuzzing. Enabling this will
 
 option(INSTALL_MAN "Install man pages." ON)
 
+set(APPEND_CPPFLAGS "" CACHE STRING "Preprocessor flags that are appended to the command line after all other flags added by the build system. This variable is intended for debugging and special builds.")
+set(APPEND_CFLAGS "" CACHE STRING "C compiler flags that are appended to the command line after all other flags added by the build system. This variable is intended for debugging and special builds.")
+set(APPEND_CXXFLAGS "" CACHE STRING "(Objective) C++ compiler flags that are appended to the command line after all other flags added by the build system. This variable is intended for debugging and special builds.")
+set(APPEND_LDFLAGS "" CACHE STRING "Linker flags that are appended to the command line after all other flags added by the build system. This variable is intended for debugging and special builds.")
+# Appending to this low-level rule variables is the only way to
+# guarantee that the flags appear at the end of the command line.
+string(APPEND CMAKE_CXX_COMPILE_OBJECT " ${APPEND_CPPFLAGS} ${APPEND_CXXFLAGS}")
+string(APPEND CMAKE_CXX_CREATE_SHARED_LIBRARY " ${APPEND_LDFLAGS}")
+string(APPEND CMAKE_CXX_LINK_EXECUTABLE " ${APPEND_LDFLAGS}")
+
 set(configure_warnings)
 
 include(CheckPIESupported)
diff --git a/cmake/module/FlagsSummary.cmake b/cmake/module/FlagsSummary.cmake
index c31cd73342..9a408f715d 100644
--- a/cmake/module/FlagsSummary.cmake
+++ b/cmake/module/FlagsSummary.cmake
@@ -29,6 +29,8 @@ function(print_flags_per_config config indent_num)
   endif()
   get_target_interface(core_cxx_flags "${config}" core_interface COMPILE_OPTIONS)
   string(STRIP "${combined_cxx_flags} ${core_cxx_flags}" combined_cxx_flags)
+  string(STRIP "${combined_cxx_flags} ${APPEND_CPPFLAGS}" combined_cxx_flags)
+  string(STRIP "${combined_cxx_flags} ${APPEND_CXXFLAGS}" combined_cxx_flags)
   indent_message("C++ compiler flags ...................." "${combined_cxx_flags}" ${indent_num})
 
   string(STRIP "${CMAKE_CXX_FLAGS} ${CMAKE_CXX_FLAGS_${config_uppercase}}" combined_linker_flags)
@@ -38,6 +40,7 @@ function(print_flags_per_config config indent_num)
   if(CMAKE_CXX_LINK_PIE_SUPPORTED)
     string(JOIN " " combined_linker_flags ${combined_linker_flags} ${CMAKE_CXX_LINK_OPTIONS_PIE})
   endif()
+  string(STRIP "${combined_linker_flags} ${APPEND_LDFLAGS}" combined_linker_flags)
   indent_message("Linker flags .........................." "${combined_linker_flags}" ${indent_num})
 endfunction()
 
diff --git a/src/CMakeLists.txt b/src/CMakeLists.txt
index 2877cc51f7..18b2b5745d 100644
--- a/src/CMakeLists.txt
+++ b/src/CMakeLists.txt
@@ -73,6 +73,7 @@ endif()
 set(CMAKE_EXPORT_COMPILE_COMMANDS OFF)
 add_subdirectory(secp256k1)
 set(CMAKE_EXPORT_COMPILE_COMMANDS ON)
+string(APPEND CMAKE_C_COMPILE_OBJECT " ${APPEND_CPPFLAGS} ${APPEND_CFLAGS}")
 
 # Stable, backwards-compatible consensus functionality.
 add_library(bitcoin_consensus STATIC EXCLUDE_FROM_ALL