diff --git a/contrib/guix/guix-build b/contrib/guix/guix-build
index 298e7bfbd6..870938cb52 100755
--- a/contrib/guix/guix-build
+++ b/contrib/guix/guix-build
@@ -74,7 +74,8 @@ mkdir -p "$VERSION_BASE"
 ################
 
 # Default to building for all supported HOSTs (overridable by environment)
-export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu powerpc64le-linux-gnu
+# powerpc64le-linux-gnu currently disabled due non-determinism issues across build arches.
+export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu
                        x86_64-w64-mingw32
                        x86_64-apple-darwin arm64-apple-darwin}"